姓名：张春雨
硕士生导师
职称：副教授
联系方式：zhangchunyu@sdfmu.edu.cn
研究方向：
1. 铂类抗肿瘤药物开发及治疗应用;
2. 基于金属团簇药物/探针的纳米生物效应研究;
3. 基于先进光源的单细胞同步辐射成像分析。
主要学术任职：
1. 担任Nano Today, Small, Molecular Pharmaceutics等期刊审稿人
主持科研课题：
1. 国家博士后科学基金, 面上项目, 2022M711974, 2022/06-2023/09, 8万元, 已结题, 主持;
2. 山东第一医科大学青年科学基金培育资助计划项目, 202201-003, 2022/10-2024/10, 10万元, 在研, 主持;
3. 山东省医药卫生科技项目, 青年项目, 202313030397, 2024/01-2025/12, 5万元, 在研, 主持;
4. 山东第一医科大学高层次人才引进经费资助项目, 2023/09-2028/08, 100万, 在研, 主持。
近五年代表性论文（限第一作者和通讯作者）：
(1) Xu, C.; Xia, D.; Zhang, X.; Yao, Q.; Wang, Y.;* Zhang, C.,* In situ analysis of metallodrugs at the single-cell level based on synchrotron radiation technology. TrAC-Trends in Analytical Chemistry 2024, 171, 117515.
(2) Zhang, C.;* Zhang, N.; Niu, W.; Li, R.; Liu, Y.; Mu, Y.; Xu, C.;* Yao, Q.;* Gao, X.,* Ultrasmall platinum nanoclusters: A potent chemotherapeutic drug for cancer-specific DNA damage with optimizing therapeutic efficacy while minimizing systemic toxicity. Nano Today 2024, 55, 102195.
(3) Zhang, C.;# Zhang, K.;# Cui, Y.;# Guo, Y.; Wang, C.; Xu, C.; Yao, Q.; Zhao, Y.; Chen, C.;* Wang, Y.,* Multifunctional Nanoprobe for 3D Nanoresolution Imaging of Intact Cell HER2 Protein with Hard X-ray Tomography. Anal. Chem. 2023, 95, 2129-2133. (Cover article)
(4) Zhang, C.;# Xu, C.;# Gao, X.;* Yao, Q.,* Platinum-based Drugs for Cancer Therapy and Anti-tumor Strategies. Theranostics 2022, 12, 2115-2132. (Highly Cited Paper)
(5) Zhang, C.; Yao, S.; Xu, C.; Chang, Y.; Zong, Y.; Zhang, K.; Zhang, X.; Zhang, L.; Chen, C.; Zhao, Y.; Jiang, H.;* Gao, X.;* Wang, Y.,* 3D Imaging and Quantification of the Integrin at a Single-Cell Base on a Multisignal Nanoprobe and Synchrotron Radiation Soft X-ray Tomography Microscopy. Anal. Chem. 2021, 93, 1237-1241.
(6) Zhang, C.; Gao, L.;* Yuan, Q.; Zhao, L.; Niu, W.; Cai, P.; Li, J.; Han, X.; He, Z.; Gao, F.; Wang, Y.; Jiang, H.; Chai, Z.; Gao, X.,* Is GSH Chelated Pt Molecule Inactive in Anti-Cancer Treatment? A Case Study of Pt6GS4. Small 2020, 16, 2002044.
(7) He, Z.;# Ye, F.;# Zhang, C.;# Fan, J.;# Du, Z.; Zhao, W.; Yuan, Q.; Niu, W.; Gao, F.; He, B.; Cao, P.; Zhao, L.; Gao, X.; Gao, X.; Sun, B.; Dong, Y.; Zhao, J.; Qi, J.; Liang, X.; Jiang, H.;* Gong, Y.;* Tan, W.;* Gao, X.,* A Comparison of Remdesivir Versus Gold Cluster in COVID-19 Animal Model: A Better Therapeutic Outcome of Gold Cluster. Nano Today 2022, 44, 101468. (co-first author）
(8) Zhang, Y.;# Zhang, C.;# Xu, C.;* Wang, X.; Liu, C.; Waterhouse, G. I. N.; Wang, Y.;* Yin, H.,* Ultrasmall Au Nanoclusters for Biomedical and Biosensing Applications: A Mini-review. Talanta 2019, 200, 432-442. (co-first author）
