韩利文

文章来源:药学院 发布时间:2024-03-23浏览次数:

姓名:韩利文

博士,研究生导师,博士后合作导师,山东省中医药高层次人才(学科带头人),山东第一医科大学(山东省医学科学院)高层次骨干人才

职称:副研究员

联系方式:hanliwen@sdfmu.edu.cn


研究方向:

1. 药物复杂成分体系的组学解析

2. 基于新型模式生物斑马鱼的药物筛选

3. 中药化学生物学作用机制


主要学术任职:

1.世界中医药联合会网络药理学分会,常务理事

2.山东省中药协会,常务理事

3.山东省中药协会数字中药分会,副会长

4.山东中西医结合学会中医药免疫专委会,常务委员,

5.中华中医药学会实验药理学委员会,青年委员

6.中华中医药学会中药化学委员会,青年委员

7.中国野生植物保护协会肉苁蓉保育委员会,委员

8.中国中药协会药食同源物质评价与利用专业委员会,委员

9.中国药理学会海洋药物药理专业委员会,委员

10.Chinese medicine》(SCI)、《中草药》、《沈阳药科大学学报》青年编委

11.兼任威海市海洋功能评价与利用工程技术研究中心主任


主要获奖情况(包括作为指导教师):

1.基于斑马鱼模型的中药心血管活性评价技术与应用,中华中医药学会科学技术奖,二等奖,2016.11,第2

2. 代谢组学创新技术的建立及在中药安全性评价和精准防治中的应用,中华中医药学会科学技术奖二等奖,2019,第3

3.基于斑马鱼模型的中药心血管活性评价技术与应用,山东省科技进步奖,二等奖,2015.11,第3

4.基于斑马鱼模型的药物发现技术体系的建立与应用,山东省科技进步奖,三等奖,2010,第3

5.中药安全性评价关键技术及转化应用,2022年中国产学研合作创新成果奖,三等奖,2023.2,第7

6.药学类专业一领二辅三融合的创新创业育人模式构建与实践,山东省第九届教学成果奖(高等教育类),二等奖,2022.03,第8

7. 高科智鱼-新一代心脑血管药物快速筛选技术引领者,第八届中国国际互联网+”大学生创新创业大赛,国赛铜奖,2023.3,第一指导教师

8.高科药筛,精准发现——国内冠心病血管再生药物筛选技术的领跑者,第五届中华职业教育创新创业大赛,国赛银奖,2021,第一指导教师

9.高科药筛,精准发现——国内冠心病血管再生药物筛选机构的领跑者,山东省第七届中国国际互联网+”大学生创新创业大赛,金奖,2021,第一指导教师

10.基于斑马鱼模型的抗冠心病药物筛选新技术及应用,第八届山东省大学生科技创新大赛,一等奖,2021,第一指导教师

11.高科智鱼-抗心脑缺血药物筛选外包服务供应商,山东省第八届中国国际互联网+”大学生创新创业大赛,铜奖,2022,第一指导教师

12.高科药筛,精准发现——国内冠心病血管再生药物筛选技术的领跑者,第十三届挑战杯山东省大学生创业计划竞赛,铜奖,第一指导教师

13.光谱分析法概论——身边的光,山东第一医科大学(山东省医学科学院)首届大学生讲课程思政比赛,一等奖,2022,第一指导教师


主持科研课题:

1.国家自然科学基金项目,81202584,利用斑马鱼模型研究血管生成相关的代谢生物标志物,2013/01-2015/1223万,主持,已结题

2.中央本级重大增减支项目-名贵中药资源可持续利用能力建设项目子课题,2060302-1907-09,利用斑马鱼模型与代谢组学技术研究文登西洋参质量标志物,2019/09-2021/1215万,主持,已结题

3.山东省自然科学基金面上项目,ZR2019MH037,基于斑马鱼模型和代谢组学技术的中药天麻抗癫痫药效标志物研究,2019/07-2022/0619万,主持,已结题

4.山东省重点研发计划项目,2016GSF121009, 新型海螺降压脂肽的高效提取及保健食品的研发,2016/12-2018/1212万,主持,已结题

5.山东省农业科技园区产业提升工程项目,2017YQ001,基于高值转化技术的海参副产物新产品研发及产业化示范,2017/04-2019/12100万,主持,已结题

6.山东第一医科大学高层次骨干人才项目,2019/12-2024/11200万,主持

7.烟台大学分子药理和药物评价教育部重点实验室开放课题基金,P220204,基于线粒体ROS稳态的拟人参皂苷F11保护血管内皮损伤的分子药理机制,2022.12-2024.115万,主持

8.山东省中医药高层次人才(学科带头人)培育项目2023/04-2026/0410万,主持

9.国家中医药管理局科技司-山东省卫生健康委员会共建中医药科技项目,重大项目,GZY-KJS-SD-2023-088,黄河三角洲耐盐碱肉苁蓉的关键活性成分辨识及质量评价研究, 2023/12- 2026/1150万,主持

10中央本级重大增减支项目名贵中药资源可持续利用能力建设子课题,2060302-2301-13,生长年限对西洋参囊泡的形成、化学组成及主要生物活性的影响2023/07-2025/1220万,主持

11.山东省自然科学基金,面上项目,ZR202211080026,新型斑马鱼慢性疲劳综合征模型的建立及西洋参关键药效物质的辨识,2024/01-2026/1210万,主持


近五年代表性论文(限第一作者和通讯作者):

1. Wang S*, Jia Q, Liu X, Ma Y, Yang Y, Rong X, Wang Y, Wang H, Liu F, Yang S, Li Y, Han L*. Hyperoside modulates bile acid and fatty acid metabolism, presenting a potentially promising treatment for non-alcoholic fatty liver disease. J Adv Res. 2025 May 9:S2090-1232(25)00308-XQ1/13.0.

2. Wenjie Bi#, Yougang Zhang#, Zixu Lu, Huanxin Zhao, Haiyang Wang, Songsong Wang, Rajiv Kumar Malhotra, Xiaojing Wang*, Liwen Han*. Matairesinol discovered as a key active ingredient in Chinese Dark Tea protects against high-fat induced endothelial injury via activating AMPK phosphorylation. J Ethnopharmacol. 2025 Mar 6:119576Q1/5.4.

3. Xiaobin Li, Chenyang Li, Yongqiang Zhu, Yongping Shi, Xuanming Zhang, Shanshan Zhang, Lizhen Wang, Hou-Wen Lin, Hairong Hou, Chung-Der Hsiao, Liwen Han*, Kechun Liu*. Lipids Fingerprinting of Different Materials Sources by UPLC-Q-Exactive Orbitrap/MS Approach and Their Zebrafish-based Activities Comparison. J Agric Food Chem, 2020,68 (7), 2007-2015Q1/4.2.

4. Yong-ping Shi#, You-gang Zhang#, Hao-nan Li, Hao-tian Kong, Shan-shan Zhang,Xuan-ming Zhang, Xiao-bin Li, Ke-chun Liu, Li-wen Han, Qing-ping Tian. Discovery and identification of antithrombotic chemical markers in Gardenia Fructus by herbal metabolomics and zebrafish model. J Ethnopharmacol, 2020253112679Q1/3.6.

5. Sha Liao#, Liwen Han#, Xiaopu Zheng, Xin Wang, Peng Zhang, Jingni Wu, Ruimin Liu, Youlan Fu, Jiaxin Sun, Ximeng Kang, Kechun Liu, Taiping Fan*, Shao Li*, Xiaohui Zheng*,.Tanshinol borneol ester (DBZ), a novel synthetic small molecule angiogenesis stimulator inspired by botanical formulations for angina pectoris. Br J Pharmacol. 2019,176 (17), 3143-3160Q1/7.8.

6.Zhang X, Shi Y, Wang L, Li X, Zhang S, Wang X, Jin M, Hsiao CD, Lin HW, Han L*, Liu K*. Metabolomics for Biomarker Discovery in Fermented Black Garlic and Potential Bioprotective Responses against Cardiovascular Diseases.J Agric Food Chem. 2019 Nov 6;67(44):12191-12198Q1/4.2.

7. Taiping Li,Yougang Zhang,Rong Dong,Wenjie Bi,Songsong Wang*,Kewu Zeng*, Liwen Han*. Identification and mechanistic exploration of key anti-inflammatory molecules in American ginseng: Impacts on signal transducer and activator of transcription 3 STAT3 phosphorylation and macrophage polarization. Phytother Res, 2024 Aug;38(8):4307-4320. (IF 6.3)

8. Xiaxia Liu, Xia Kong, Li Xu, Yonghui Su, Shanshan Xu, Xiaoya Pang, Ruifen Wang, Yihan Ma, Qingping Tian*, Liwen Han*. Synergistic therapeutic effect of ginsenoside Rg3 modified minoxidil transfersomes (MXD-Rg3@TFs) on androgenic alopecia in C57BL/6 mice. Int J Pharm., 2024, Volume 654, 123963

9. Haiyang Wang, Ying Sun, Yonghong Xie*, Fusheng Liu*, Liwen Han*. Identification of key anti-inflammatory components of green prickly ash fruit based on zebrafish model and activity tracking strategy. J Funct Foods, 2023,17,105656.

10. Taiping Li,Huan Wang,Wenjie Bi,Yonghui Su,Yongai Xiong,Songsong Wang* and Liwen Han*. Nano-Characterization, Composition Analysis, and Anti-Inflammatory Activity of American-Ginseng-Derived Vesicle-like Nanoparticles. Molecules. 2024 Jul 23;29(15):3443. doi: 10.3390/molecules29153443.Molecules, 2024, 29, 3443.

11. Hu K, Wang H, Wang H, Li T, Liu L, Zhang H, Li Z, Wang S*, Han L*. Lipid discovered in American ginseng alleviates doxorubicin-induced cardiotoxicity by inhibiting cardiomyocyte ferroptosis. Fitoterapia. 2024 Sep:177:106097.

12. Yonghui Su#, Shanshan Xu#, Xinqi Hu, Ruifen Wang, Mengxuan Dong, Yihan Wang, Songsong Wang, Yougang Zhang, Qingping Tian*, Liwen Han*. Rapid discovery of natural skin-lightening ingredients based on an integrated screening strategy based on molecular docking and zebrafish model. J Cosmet Dermatol. 2024 Nov;23(11):3724-3734.

13Rong Dong, Yougang Zhang, Shanjun Chen, Huan Wang, Kaiqing Hu, Huanxin Zhao, Qingping Tian, Kewu Zeng, Songsong Wang* and Liwen Han*. Identification of Key Pharmacodynamic Markers of American ginseng against Heart Failure Based on Metabolomics and Zebrafish Model. Front. Pharmacol.,2022,13: 909084

14. Dandan Deng1, Borong Zhao 1, Hong Yang 1, Songsong Wang 2, Ziying Geng 1, Jiangtao Zhou 1, Guane Yang 1,*and Liwen Han2,*. Investigating the Effect and Potential Mechanism of Rhamnetin 3-O-α-Rhamnoside on Acute Liver Injury In Vivo and In Vitro. Pharmaceuticals, 2025, 18, 116 (Q3/4.8)

15. You-Gang Zhang#, Xia-Xia Liu#, Jian-Cheng Zong#, Yang-Teng-Jiao Zhang, Rong Dong, Na Wang, Zhi-Hui Ma, Li Li, Shang-Long Wang, Yan-Ling Mu, Song-Song Wang, Zi-Min Liu* and Li-Wen Han *. Investigation Driven by Network Pharmacology on Potential Components and Mechanism of DGS, a Natural Vasoprotective Combination, for the Phytotherapy of Coronary Artery Disease. Molecules, 2022, 27(13), 4075

16. Zhang X, Kong C, Wang X, Hou H, Yu H, Wang L, Li P, Li X, Zhang Y, Han L*, Liu K*. LC-MS analysis of ginsenosides in different parts of Panax quinquefolius and their potential for coronary disease improvement. Planta Med. 2023 Mar 20.

17. Kong H#, Wang S#, Zhang Y, Zhang Y, He Q, Dong R, Zheng X*, Liu K* and Han L*. Promoting Angiogenesis Effect and Molecular Mechanism of Isopropyl Caffeate (KYZ), a Novel Metabolism-Derived Candidate Drug, Based on Integrated Network Pharmacology and Transgenic Zebrafish Models. Front. Pharmacol. 2022, 13:901460.

18. Rong Dong, Qingping Tian, Yongping Shi, Shanjun Chen, Yougang Zhang, Zhipeng Deng, Xiaojing Wang, Qingqiang Yao and Liwen Han*.An Integrated Strategy for Rapid Discovery and Identification of Quality Markers in Gardenia Fructus using an Omics Discrimination-Grey Correlation-Biological Verification Method. Front Pharmacol. 2021 Jun 24;12:705498.

19. Gilbert Audira#, Bonifasius Putera Sampurna#, Stevhen Juniardi, Sung-Tzu Liang, Yu-Heng Lai, Liwen Han* and Chung-Der Hsiao*. Establishing simple image-based methods and a cost-effective instrument for toxicity assessment on circadian rhythm dysregulation in fish. Biology Open2019 Jun8 (6) .bio041871.

20. Liwen Han#, Qing Xia#, Lei Zhang, Xuanming Zhang, Xiaobin Li, Shanshan Zhang, Lizhen Wang, Changxiao Liu*,Kechun Liu. Induction of developmental toxicity and cardiotoxicity in zebrafish embryos/larvae by Acetyl-11-keto-β-boswellic acid (AKBA) through oxidative stress. Drug and chemical toxicology, 2019 Oct ,28:1-8.


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