陈启鑫

文章来源:药学院 发布时间:2024-04-22浏览次数:

姓名:陈启鑫

博士生导师

职称:研究员

联系方式:chenqixin@sdfmu.edu.cn

研究方向:

1. 中药化学生物学

2. 药效物质超分辨荧光成像示踪与分析

主要学术任职:

1. 中国生物化学与分子生物学会工业专业分会 委员

2. 山东省医学伦理学会转化医学分会 常务理事

3. Advanced Drug Delivery Reviews 组稿编辑

4. 担任Research、Exploration、Chinese Chemical Letters、Asian Journal of Pharmaceutical Sciences、Acta Materia Medica等期刊青年编委

主要获奖情况(包括作为指导教师):

1. 山东省医学科技奖

2. 山东省药学会科技奖

3. 山东省普通高等学校教师教学创新大赛二等奖

4. 第九届山东省大学生科技创新大赛二等奖(指导教师)

主持科研课题:

1. 中国科协青年人才托举工程,YESS20230165, 2023.10-2025.5, 30万元, 在研, 主持。

2. 国家自然科学基金 青年基金,22107059,2022/01-2024.12,30万元, 在研, 主持。

3. 山东省重大科技创新工程,2021CXGC010501,2022/01-2024.12,82万元, 在研, 主持。

4. 泰山学者工程 青年专家,TSQN202211221, 2022/07-2025/06,75 万元,在研, 主持。

5. 山东省自然科学基金:优秀青年基金,ZR2022YQ66, 2023/01-2025/12, 50万元,在研, 主持。

6. 山东省高等学校“青创科技支持计划”,2021KJ035, 2022/01-2024/12, 50万元,在研, 主持。

7. 山东省自然科学基金:青年基金,ZR2021QH057, 2022/01-2024/12, 15万元,在研, 主持。

近五年代表性论文(限第一作者和通讯作者):

1Qixin Chen#, Hongbao Fang#, Xintian Shao, Zhiqi Tian, Shanshan Geng, Yuming Zhang, Huaxun Fan, Pan Xiang, Jie Zhang, Xiaohe Tian, Kai Zhang*, Weijiang He*, Zijian Guo*, Jiajie Diao*. A dual-labeling probe to track functional mitochondria–lysosome interactions in live cells. Nature Communications, 2020, 11, 6290. IF=17.7

2Qixin Chen#*, Liu-Yi Liu#, Zhiqi Tian#, Zhou Fang, Kang-Nan Wang,Xintian Shao, Chengying Zhang, Weiwei Zou, Fiona Rowan, Kangqiang Qiu, Baohua Ji, Jun-Lin Guan, Dechang Li*, Zong-Wan Mao*, Jiajie Diao*. Mitochondrial nucleoid condensates induce peripheral fission through high membrane curvature. Cell Reports, 2023, 42, 113472. IF=8.8

3Kai Wang, Ruixiao Zhang, Xiujie Zhao*, Yan Ma, Lijuan Ren, Youxiao Ren, Gaofei Chen, Dingming Ye,Jinfang Wu, Xinyuan Hu, Yuanqiang Guo, Rimo Xi, Meng Meng, Qingqiang Yao*, Ping Li*, Qixin Chen*, Tony D. James*. Reversible recognition-based boronic acid probes for glucose detection in live cells and zebrafish. Journal of the American Chemical Society, 2023,145, 15, 8408. IF=15.0

4Guiqian Fang#, Daili Liu#, Mengrui Zhang, Liwei Shao, Xintian Shao, Jia Chen, Caicai Meng, Yanfeng Wang, Kewu Zeng, Qixin Chen*. Single-organelle localization-based superresolution imaging for subcellular molecules micro-dynamics. Coordination Chemistry Reviews, 2024,504,215670. IF=20.4

5Xintian Shao, Caicai Meng, Wenjing Song, Tao Zhang, Qixin Chen*. Subcellular visualization: organelle-specific targeted drug delivery and discovery. Advanced Drug Delivery Reviews, 2023,114977. IF=17.8

6)Huimin Chen, Guiqian Fang, Youxiao Ren, Weiwei Zou, Kang Ying, Zhiwei Yang, Qixin Chen*. Super-resolution imaging for in situ monitoring sub-cellular micro-dynamics of small molecule drug. Acta Pharmaceutica Sinica B, 2023, 10.1016/j.apsb.2023.11.022. IF=14.5

7Ting Sun#, Huanxin Zhao#, Luyao Hu, Xintian Shao, Zhiyuan Lu,Yuli Wang, Peixue Ling, Yubo Li*, Kewu Zeng*, Qixin Chen*. Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms. Acta Pharmaceutica Sinica B, 2024, 10.1016/j.apsb.2024.01.018. IF=14.5

8Guiqian Fang, Huimin Chen, Xintian Shao*,Han Wang, Dongxue Zhan, Rang Wang, Peng Meng, Hongbao Fang, Fei Liu, Peixue Ling, Zhongyu Wu, Jiajie Diao, Qingqiang Yao*, Qixin Chen*. Single image capture of bioactive ion crosstalk within inter-organelle membrane contacts at nanometer resolution. Small Methods, 2022, 6, 200321. IF=15.4

9Yongchun Wei, Lingxiu Kong, Huimin Chen, Yuanyuan Liu, Yifei Xu, Han Wang, Guiqian Fang, Xintian Shao, Yanfeng Wang*, Qixin Chen*. Super-resolution image based tracking of drug distribution in mitcchondria of a label-free naturally derived drug molecules. Chemical Engineering Journal, 2022,132134. IF=16.7

10)Kang-Nan Wang#, Xintian Shao#, Zhiqi Tian#, Liu-Yi Liu#, Chengying Zhang#, Cai-Ping Tan, Jie Zhang, Peixue Ling, Fei Liu, Qixin Chen*, Jiajie Diao*, Zong-Wan Mao*. A continuous add-on probe reveals the nonlinear enlargement of mitochondria in light-activated oncosis. Advanced Science, 2021,202004566. IF=17.5

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