姓名：刘婷婷
硕士生导师
职称：副教授
联系方式：liutingting@sdfmu.edu.cn; 15853121615@163.com
课题组主页：http://www.x-mol.com/groups/tina-liu
研究方向：
1. 靶向肿瘤小分子荧光探针的设计、合成及评价研究
2. 靶向肿瘤的小分子抑制剂的设计、合成及评价研究
主要学术任职：
1. 山东生物医学工程学会医美药分子工程专业委员会，委员；
2. J. Med. Chem., Eur. J. Med. Chem.等期刊审稿人；
主要获奖情况（包括作为指导教师）：
1. “科巢杯”第九届山东省大学生医药生物技术技能大赛一等奖，山东省教育厅，2022；
2. 第八届全国大学生基础医学创新实验设计大赛东部赛区优秀奖，高等学校国家级实验教 学示范中心联席会，2022；
3. 山东省微课比赛二等奖，山东省教育厅，2022；
4. 山东省青年教学大赛优秀奖，山东省教育厅，2022；
5. 全国第二届“智慧树杯”课程思政示范案例教学大赛一等奖，智慧树网，2022；
6. 于金明科技创新奖，山东第一医科大学，2021；
7. 山东省课程思政示范案例三等奖，山东省高等医学教育研究中心，2021；
主持科研课题：
1. 国家自然科学基金青年基金项目，8210131454，新型BRD4荧光探针的构建及其在乳腺癌成像分析中的应用研究，2022.01-2024.12，30万元，主持。
2. 山东省自然科学基金青年项目，ZR2020QH344，新型环境敏感型 Mcl-1 荧光探针的设计、合成及成像应用研究，2021.01-2023.12，14万元，主持。
3. 山东省医药卫生科技发展计划项目，2019WS393，新型环境敏感型Mcl-1荧光探针的设计、合成及生物成像应用研究，2020.06-2022.06，2万元，已结题。
近五年代表性论文（限第一作者和通讯作者）：
1. Yuqi Gao1, Jie Zhang 1, JianJun Li, Shubin Song, Sitao Zhang, Qiao Liu, Xu Wang, Jinbo Zhao, Chengcai Xia, Yuliang Xiao**, Tingting Liu*. Establishment of environment-sensitive probes targeting BRD3/BRD4 for imaging and therapy of tumor, European Journal of Medicinal Chemistry, 2023, 257, 115478.
2. Yingfei Liu, Jianjun Li, Guanghui Zhou, Jiale Zhang, Yu Teng, Zhushuang Bai*, Tingting Liu*. Design, synthesis and anticancer activity studies of novel indole derivatives as Bcl-2/Mcl-1 dual inhibitors. Medicinal Chemistry Research, 2023, 32, 99-108.
3. Wenwen Cao, Yu Zhu, Fapu Wu, Yang Tian, Zhaoming Chen, Weijia Xu, Senyao Liu, Tingting Liu*, and Hu Xiong*. Three Birds with One Stone: Acceptor Engineering of Hemicyanine Dye with NIR-II Emission for Synergistic Photodynamic and Photothermal Anticancer Therapy. Small, 2022,18, 2204851.
4. Jie Zhang, Yuqi Gao, Zipeng Zhang, Jinbo Zhao, Wenshuang Jia, Chengcai Xia, Fugang Wang*, Tingting Liu*. Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment. Journal Medicinal Chemistry, 2022, 65, 16099−16127.
5. Tingting Liu*, Shubin Song, Xu Wang, Jifu Hao. Small-molecule inhibitors of breast cancer-related targets: Potential therapeutic agents for breast cancer. European Journal of Medicinal Chemistry, 2021, 210, 112954.
6. Zheng Zhang#, Xiaolan Xing#, Peng Guan, Shubin Song, Guirong You, Chengcai Xia, Tingting Liu*. Recent progress in agents targeting polo-like kinases: Promising therapeutic strategies. European Journal of Medicinal Chemistry, 2021, 217, 113314.
7. Sitao Zhang, Yanzhao Chen, Chengsen Tian, Yujing He, Zeru Tian, Yichao Wan and Tingting Liu*. Dual-target inhibitors based on BRD4: Novel therapeutic approaches for cancer. Current Medicinal Chemistry, 2021, 28, 1775-1795
8. Tingting Liu*, Yichao Wan, Yuliang Xiao, Chengcai Xia, Guiyun Duan. Dual-target inhibitors based on HDACs: Novel antitumor agents for cancer therapy. Journal of Medicinal Chemistry, 2020, 63, 8977-9002.
9. Tingting Liu*, Zhongyu Wu, Yujing He, Yuliang Xiao, Chengcai Xia. Single and dual target inhibitors based on Bcl-2: Promising anti-tumor agents for cancer therapy. European Journal of Medicinal Chemistry, 2020, 201, 112446-112458.
10. Yichao Wan*, Chunxing Yan, Han Gao, Tingting Liu*. Small-molecule PROTACs: Novel agents for cancer therapy. Future Medicinal Chemistry, 2020, 12, 1756-8919.
11. Tingting Liu, Gaopan Dong, Feng Xu, Bowen Han, Hao Fang, YunHuang, Yubin Zhou, Lupei Du, Minyong Li*. Discovery of turn-On fluorescent probes for detecting Bcl-2 Protein. Analytical Chemistry, 2019, 91, 5722-5728.
12. Tingting Liu, Yuqi Gao, Xiaomeng Zhang, Yichao Wan, Lupei Du, Hao Fang, Minyong Li*. Discovery of a turn-On fluorescent probe for myeloid cell leukemia‑1 protein. Analytical Chemistry, 2017, 89, 11173-11177.
13. Tingting Liu, Yichao Wan, Renshuai Liu, Lin Ma, Minyong Li, Hao Fang*. Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. Bioorganic & Medicinal Chemistry, 2017, 25, 1939-1948.
14. Tingting Liu#, Yan Jiang#, Zhenzhen Liu, Jin Li, Kun Fang, Chunlin Zhuang, Lupei Du, Hao Fang, Chunquan Sheng* and Minyong Li*. Environment-sensitive turn-on fluorescent probes for p53-MDM2 protein-protein interaction. MedChemComm, 2017, 8, 1727-1732.
