刘婷婷

文章来源: 发布时间:2023-07-04浏览次数:


姓名:刘婷婷

硕士生导师

职称:副教授

联系方式:liutingting@sdfmu.edu.cn; 15853121615@163.com

课题组主页:http://www.x-mol.com/groups/tina-liu


研究方向:

1. 靶向肿瘤小分子荧光探针的设计、合成及评价研究

2. 靶向肿瘤的小分子抑制剂的设计、合成及评价研究


主要学术任职:

1. 山东生物医学工程学会医美药分子工程专业委员会,委员;

2. J. Med. Chem., Eur. J. Med. Chem.等期刊审稿人


主要获奖情况(包括作为指导教师):

1. 科巢杯第九届山东省大学生医药生物技术技能大赛一等奖,山东省教育厅2022

2. 第八届全国大学生基础医学创新实验设计大赛东部赛区优秀奖,高等学校国家级实验教          学示范中心联席会,2022

3. 山东省微课比赛二等奖,山东省教育厅,2022

4. 山东省青年教学大赛优秀奖,山东省教育厅,2022

5. 全国第二届智慧树杯课程思政示范案例教学大赛一等奖,智慧树网,2022

6. 于金明科技创新奖,山东第一医科大学,2021

7. 山东省课程思政示范案例三等奖,山东省高等医学教育研究中心,2021


主持科研课题:

1. 国家自然科学基金青年基金项目,8210131454,新型BRD4荧光探针的构建及其在乳腺癌成像分析中的应用研究,2022.01-2024.1230万元,主持。

2. 山东省自然科学基金青年项目,ZR2020QH344,新型环境敏感型 Mcl-1 荧光探针的设计、合成及成像应用研究,2021.01-2023.1214万元,主持。

3. 山东省医药卫生科技发展计划项目,2019WS393,新型环境敏感型Mcl-1荧光探针的设计、合成及生物成像应用研究,2020.06-2022.062万元,已结题。

近五年代表性论文(限第一作者和通讯作者):

1. Yuqi Gao1, Jie Zhang 1, JianJun Li, Shubin Song, Sitao Zhang, Qiao Liu, Xu Wang, Jinbo Zhao, Chengcai Xia, Yuliang Xiao**, Tingting Liu*. Establishment of environment-sensitive probes targeting BRD3/BRD4 for imaging and therapy of tumor, European Journal of Medicinal Chemistry, 2023, 257, 115478.

2. Yingfei Liu, Jianjun Li, Guanghui Zhou, Jiale Zhang, Yu Teng, Zhushuang Bai*, Tingting Liu*. Design, synthesis and anticancer activity studies of novel indole derivatives as Bcl-2/Mcl-1 dual inhibitors. Medicinal Chemistry Research, 2023, 32, 99-108.

3. Wenwen Cao, Yu Zhu, Fapu Wu, Yang Tian, Zhaoming Chen, Weijia Xu, Senyao Liu, Tingting Liu*, and Hu Xiong*. Three Birds with One Stone: Acceptor Engineering of Hemicyanine Dye with NIR-II Emission for Synergistic Photodynamic and Photothermal Anticancer Therapy. Small, 2022,18, 2204851.

4. Jie Zhang, Yuqi Gao, Zipeng Zhang, Jinbo Zhao, Wenshuang Jia, Chengcai Xia, Fugang Wang*, Tingting Liu*. Multi-therapies Based on PARP Inhibition: Potential Therapeutic Approaches for Cancer Treatment. Journal Medicinal Chemistry, 2022, 65, 16099−16127.

5. Tingting Liu*, Shubin Song, Xu Wang, Jifu Hao. Small-molecule inhibitors of breast cancer-related targets: Potential therapeutic agents for breast cancer. European Journal of Medicinal Chemistry, 2021, 210, 112954.

6. Zheng Zhang#, Xiaolan Xing#, Peng Guan, Shubin Song, Guirong You, Chengcai Xia, Tingting Liu*. Recent progress in agents targeting polo-like kinases: Promising therapeutic strategies. European Journal of Medicinal Chemistry, 2021, 217, 113314.

7. Sitao Zhang, Yanzhao Chen, Chengsen Tian, Yujing He, Zeru Tian, Yichao Wan and Tingting Liu*. Dual-target inhibitors based on BRD4: Novel therapeutic approaches for cancer. Current Medicinal Chemistry, 2021, 28, 1775-1795

8. Tingting Liu*, Yichao Wan, Yuliang Xiao, Chengcai Xia, Guiyun Duan. Dual-target inhibitors based on HDACs: Novel antitumor agents for cancer therapy. Journal of Medicinal Chemistry, 2020, 63, 8977-9002.

9. Tingting Liu*, Zhongyu Wu, Yujing He, Yuliang Xiao, Chengcai Xia. Single and dual target inhibitors based on Bcl-2: Promising anti-tumor agents for cancer therapy. European Journal of Medicinal Chemistry, 2020, 201, 112446-112458.

10. Yichao Wan*, Chunxing Yan, Han Gao, Tingting Liu*. Small-molecule PROTACs: Novel agents for cancer therapy. Future Medicinal Chemistry, 2020, 12, 1756-8919.

11. Tingting Liu, Gaopan Dong, Feng Xu, Bowen Han, Hao Fang, YunHuang, Yubin Zhou, Lupei Du, Minyong Li*. Discovery of turn-On fluorescent probes for detecting Bcl-2 Protein. Analytical Chemistry, 2019, 91, 5722-5728.

12. Tingting Liu, Yuqi Gao, Xiaomeng Zhang, Yichao Wan, Lupei Du, Hao Fang, Minyong Li*. Discovery of a turn-On fluorescent probe for myeloid cell leukemia‑1 protein. Analytical Chemistry, 2017, 89, 11173-11177.

13. Tingting Liu, Yichao Wan, Renshuai Liu, Lin Ma, Minyong Li, Hao Fang*. Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. Bioorganic & Medicinal Chemistry, 2017, 25, 1939-1948.

14. Tingting Liu#, Yan Jiang#, Zhenzhen Liu, Jin Li, Kun Fang, Chunlin Zhuang, Lupei Du, Hao Fang, Chunquan Sheng* and Minyong Li*. Environment-sensitive turn-on fluorescent probes for p53-MDM2 protein-protein interaction. MedChemComm, 2017, 8, 1727-1732.


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