姓名：李玉磊
博士生导师，博士后合作导师，泰山学者青年专家；
职称：副教授
联系方式：fengyunliyu@sina.com; 课题组网站：https://www.x-mol.com/groups/Li_Lab
研究方向：
1、 化学合成新方法、策略用于环肽药物的研发；
2、 多肽药物化学（抗肿瘤、抗菌、抗病毒多肽的开发）；
3、 发展新方法策略用于翻译后修饰蛋白质化学全合成；
主要学术任职：
1. 中国化学会会员
2. 青年泰山学者
获奖情况：
清华大学博士后创新奖；
“建行杯”山东省大学生创新大赛铜奖（指导老师）；
主持科研课题：
1. 清华大学-北京大学生命联合中心基金，药用双环肽的全自动合成技术，2019/11/11- 2021/10/31, 24万，已结题；
2. 国家自然科学基金青年项目，22207065，翻译后修饰靶标蛋白的化学合成，2023/01- 2025/12，30万，在研；
3. 山东省青年泰山学者项目，2023-2025，抗耐药菌多肽的开发，75万，在研；
4. 山东第一医科大学高层次人才经费，2022-2026，200万，在研；
近五年代表性论文（限第一作者和通讯作者）：
1. Xiang Li#, Yanjiao Ding#, Jingwen Xue#, Yinxue Fu, Fang Yan, Nannan Song, Honggang Hu, Wei Cong*, Zhiyuan Lu*, Yulei Li*. Peptide Double-Stapling and Arginine N‑Glycosylation Triggered the Development of Therapeutic Antimicrobial Peptides Capable of Killing Drug-Resistant Bacteria in Mice. Journal of Medicinal Chemistry, 2025, 68, 4, 4511–4526.
2. H. Liu, X. Dai, N. Li, L. Zhang, Z. Wang, K. Ren, Yulei Li* X. Sun*, J. Wan*. Injectable Magnetic Hydrogel Incorporated with Anti-inflammatory Peptide for Efficient Magnetothermal Treatment of Endometriosis. Advanced Science, 2024, 11(44): 2409778.
3. Yulei Li*, Minghao Wu, Yinxue Fu, Jingwen Xue, Fei Yuan, Tianci Qu, Anastassia N. Rissanou, Yilin Wang, Xiang Li*, Honggang Hu*. Therapeutic stapled peptides: Efficacy and molecular targets，Pharmacological Research，2024, 203: 107137.
4. Wei Cong, Huaxing Shen, Xiufei Liao, Mengjun Zheng, Xianglong Kong, Zhe Wang, Si Chen, Yulei Li*, Honggang Hu*, Xiang Li*. Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice. Acta Pharm Sin B 2023, 13(9): 3770-3781.
5. Jingwen; Yinxue Fu; XueHuang Li; Ting Zhang; Wei Cong; Honggang Hu; Zhiyuan Lu; Fang Yan*; Yulei Li*. All-hydrocarbon stapling enables improvement of antimicrobial activity and proteolytic stability of peptide Figainin 2, Journal of Peptide Science, 2024, 30(6): e3566.
6. Hao Yang, Fei Yuan, Guangxu Xie, Yinxue Fu, Jia Mi, Longjie Yu, Weijia Liu, Yulei Li*, ChemBioChem 2025, e202500204.
7. YuLei, Li, Heng Jie, Sun Demeng *, Zhang Baochang, Zhang Xin, Zheng Yu-Peng, Shi Wei-Wei, Wang Tong-Yue, Li Jiu-Yi, Sun Xiaoou, Liu Xiangyu, Zheng Ji-Shen*, Kobilka Brian K., Liu Lei *. Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor β2-Adrenergic Receptor with Defined Modification Patterns at the C-Terminus. J. Am. Chem. Soc. 2021, 143, 42, 17566–17576.
8. Yulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Xia Zhao*. Improving selectivity, proteolytic stability, and antitumor activity of host defense peptide hymenochirin-1B: A novel glycosylated staple strategy, ACS Chemical Biology, 2019, 14, 516-525.
9. Ye Wu#, Yulei Li#, Wei Cong, Yan Zou, Xiang Li, Honggang Hu. Total synthesis of TRADD death domain with arginine N-GlcNAcylation by hydrazide-based native chemical ligation, Chinese Chemical Letters, 2020, 31, 107-110.
10. YuLei, Li, Qian Qu, Yun-Kun Qi, Lei Liu, Ke Wei Wang, Yani Liu*, Ge-Min Fang*. Comparison of different strategies towards the chemical synthesis of long-chain scorpion toxin AaH-II. J Pep Sci. 2022;28: e3365.
11. Shi, Wei-Wei; Shi, Chaowei; Wang, Tong-Yue; Li, Yulei; Zhou, Yong-Kang; Zhang, Xu-Han; Berer, Donald; Zheng, Ji-Shen; Liu, Lei; Total Chemical Synthesis of Correctly Folded Disulfide-Rich Proteins Using a Removable O-Linked β-N-Acetylglucosamine Strategy., J. Am. Chem. Soc., 2022, 144(1): 349-357.
