姓名：李玉磊，硕士生导师, 博士后合作导师，青年泰山学者；
职称：副教授
联系方式：fengyunliyu@sina.com; 课题组网站：https://www.x-mol.com/groups/Li_Lab
研究方向：
1、 化学合成新方法、策略用于环肽药物的研发；
2、 多肽药物化学（抗肿瘤、抗菌、抗病毒多肽的开发）；
3、 发展新方法策略用于翻译后修饰蛋白质化学全合成；
主要学术任职：
1. 中国化学会会员
2. 青年泰山学者
主要获奖情况（包括作为指导教师）：
清华大学博士后创新奖
主持科研课题：
1. 清华大学-北京大学生命联合中心基金，药用双环肽的全自动合成技术，2019/11/11- 2021/10/31, 24万，已结题；
2. 国家自然科学基金青年项目，22207065，翻译后修饰靶标蛋白的化学合成，2023/01- 2025/12，30万，在研；
3. 山东省青年泰山学者项目，2023-2025，抗耐药菌多肽的开发，75万，在研；
4. 山东第一医科大学高层次人才经费，2022-2026，200万，在研；
近五年代表性论文（限第一作者和通讯作者）
[1] YuLei, Li, Heng Jie, Sun Demeng *, Zhang Baochang, Zhang Xin, Zheng Yu-Peng, Shi Wei-Wei, Wang Tong-Yue, Li Jiu-Yi, Sun Xiaoou, Liu Xiangyu, Zheng Ji-Shen*, Kobilka Brian K., Liu Lei *. Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor β2-Adrenergic Receptor with Defined Modification Patterns at the C-Terminus. J. Am. Chem. Soc. 2021, 143, 42, 17566–17576.
[2] Wei Cong, Huaxing Shen, Xiufei Liao, Mengjun Zheng, Xianglong Kong, Zhe Wang, Si Chen, Yulei Li*, Honggang Hu*, Xiang Li*, Discovery of an orally effective double-stapled peptide for reducing ovariectomy-induced bone loss in mice, Acta Pharmaceutica Sinica B, 2023 (Accepted, co-auther).
[3] Yulei Li, Yihan Zhang, Minghao Wu, Qi Chang, Xia Zhao*. Improving selectivity, proteolytic stability, and antitumor activity of host defense peptide hymenochirin-1B: A novel glycosylated staple strategy, ACS Chemical Biology, 2019, 14, 516-525.
[4] Yulei Li, Minghao Wu, Qi Chang, and Xia Zhao*. Stapling strategy enables to improve antitumor activity and proteolytic stability of host-defense peptide hymenochirin-1B, Rsc Advances, 2018, 8, 22268-22275.
[5] Yulei Li, Qi Chang, Minghao Wu, and Xia Zhao*. Total synthesis of five proline-enriched cyclic heptapeptides from the marine sponge Stylissa carteri. Tetrahedron Letters, 2018, 59, 1828–1831.
[6] Ye Wu, Yulei Li, Wei Cong, Yan Zou, Xiang Li, Honggang Hu. Total synthesis of TRADD death domain with arginine N-GlcNAcylation by hydrazide-based native chemical ligation, Chinese Chemical Letters, 2020, 31, 107-110. (co-auther)
[7] Xiang Li, Yulei Li, Yan Chen, Yan Zou, Xiaobin Zhuo, Qiuye Wu, Qingjie Zhao* and Honggang Hu* A silver-promoted solid-phase guanidylation process enables the first total synthesis of stictamide A, Rsc Advances, 2015, 5, 94654-94657. (co-auther)
[8] Yulei Li, Xuecui Bao, Yuanyuan Gao, Chao Liu, Yan Zou*, and Fang Yan*. Total synthesis of cyclic heptapeptide Stylissatin A, Chemistry of Natural Compounds, 2016, 52, 1069-1072.
[9] Yulei Li, Qi Chang, Wenwei Han, Xia Zhao*. Total synthesis of cyclic octapeptide reniochalistatins E, Chemistry of natural compounds, 2018, 54, 1131-1134.
[10] Yulei Li, Minghao Wu, Qi Chang, Xia Zhao* Solid-phase synthesis of cyclic octapeptide Phakellistatin 15, Chemistry of Natural Compounds 2019, 55, 520-524.
[11] YuLei, Li, Qian Qu, Yun-Kun Qi, Lei Liu, Ke Wei Wang, Yani Liu*, Ge-Min Fang*. Comparison of different strategies towards the chemical synthesis of long-chain scorpion toxin AaH-II. J Pep Sci. 2022;28: e3365.
[12] Shi, Wei-Wei; Shi, Chaowei; Wang, Tong-Yue; Li, Yulei; Zhou, Yong-Kang; Zhang, Xu-Han; Berer, Donald; Zheng, Ji-Shen; Liu, Lei; Total Chemical Synthesis of Correctly Folded Disulfide-Rich Proteins Using a Removable O-Linked β-N-Acetylglucosamine Strategy., J. Am. Chem. Soc., 2022, 144(1): 349-357.
