个人工作照
姓名： 徐巍
职称： 主任药师
职务： 山东第一医科大学（山东省医学科学院）第一临床学院 副院长
联系邮箱：weixu@sdu.edu.cn, wxu@email.sdfmu.edu.cn
联系电话：TEL: 0531-89269716；17686791319
研究方向：
肿瘤微环境的智能纳米递药系统构建
免疫治疗增敏策略的创新发现与评价
主要学术任职：
美国北卡罗来纳大学教堂山分校（UNC）访问学者
意大利国家肿瘤研究中心访问学者
山东省青年医务工作者协会理事、常务理事、副会长
山东生物医学工程学会组织修复与再生委员会副主任委员
山东中医药学会中药制剂分会专业委员会副主任委员
山东省医学会临床个体化用药检测与指导分会副主任委员
主要获奖情况：
山东医学科技三等奖（首位），2020
山东省医务职工优秀科技创新成果二等奖（首位），2024
齐鲁卫生与健康杰出青年人才，2020
山东省高层次人才，2020
济南市高层次人才，2021
指导研究生获得1项国家奖学金，2025
主持科研课题：
1. 泰山学者青年专家项目；2023.01-2025.12，在研
2. 山东省自然科学基金面上项目；2025.10.09-2029.09，在研
3. 国家中医药管理局科技司科技共建项目；2024.12-2026.12，在研
4. 山东省医学会科技计划项目；2025.12-2028.12，在研
5. 济南市临床医学科技创新计划项目；2025.08-2028.08，在研
6. 国家自然科学基金；2016.01-2018.12，结题
7. 山东省自然科学基金，2022.01-2024.12，结题
8. 中国博士后科学基金第71批面上项目；2022.07-2024.70，结题
9. 山东省博士后创新项目；2021.11-2023.10，结题
10. 山东省重点研发计划；2017.09-2019.08，结题
11. 济南市临床医学科技创新计划项目；2021.1-2022.12，结题
近五年代表性论文（限第一作者和通讯作者）：
1. Yixuan Tan, Shan Lu, Wanjun Liang, Yujing He, Jifu Hao, Wei Xu*, Yuansong Sun*, Changyou Zhan*. Long-acting lipid-based nanomedicines: rethinking from structure-based rational design to in vivo fate evaluation. Journal of Controlled Release. 2025, 389:114465. 2025.11.24. IF=11.5
2. Xuehui Duan†, Yixuan Tang*,†, Zhongjie Tang, Yan Du, Xinlei Chu, Xinlong Liu, Zhanyan Liu, Kun Zhao, Wei Xu*, Chong Li*. Dichotomous role of CD47-SIRPα axis: Leveraging opposing functions in phagocytic resistance and transport assistance for enhanced nanocarrier biocompatibility and tumor penetration. Acta Pharmaceutica Sinica B. 2025, https://doi.org/10.1016/j.apsb. 2025.11.13. IF=14.6
3. Zhonghua Dong, Xiao Li, Xuan Wang, Jingya Xu, Wei Xu*. Ergosterol from edible fungi: Enhancing fatty acid oxidation via CPT1A to protect against diabetic kidney disease. Food & Function. 2025, 16(16):6599-6611. doi: 10.1039/d5fo00371g. 2025-08-11. IF=5.4
4. Haiping Hu, Shuaiguang Li, Yao Zhou, Hui Lv, Zhonghua Dong, Yujia Wang, Juzheng Sheng, Xue Wang, Wenfei Fan, Wei Xu*. A 'two-missile' nanoplatform for targeting triple-negative breast cancer: prodrug activation and immune enhancement. Materials Today Bio. 2025, 32:101891. 2025.05.20. IF=10.2
5. Haixia Shen, Shuaiguang Li, Liyuan Lin, Qian Wu, Zhonghua Dong, Wei Xu*. Advancements in plant-derived exosome-like vesicles: Versatile bioactive carriers for targeted drug delivery systems. Journal of Pharmaceutical Analysis, 2025, 101300. 2025.04.11. IF=8.9
6. Jiangrui Wang, Xuewei Liang, Yan Du, Zhongjie Tang, Xuehui Duan, Zewei Sun, Jianquan Zhao, Wei Xu*, Yingyi Wang, Yixuan Tang*. Enhancement of oral bioavailability of celastrol by chitosan microencapsulated porous starch carriers. International Journal of Biological Macromolecules, 2024, 282(Pt 5): 137167. 2024.11.05. IF=8.5
7. Jianjun Ge, Ke Zhou, Yuanyuan Li, Haoxin Li, Fang Chen, Lingbing Li*, Wei Xu*. Human serum albumin and sialic acid co-modified liposome nanoreactors with tumor-specific activable cascade reactions for cooperative cancer therapy. Journal of Drug Delivery Science and Technology, 2024, 92:105343. 2024-01-04. IF=4.5
8. Hanxiao Liu, Hui Lv, Xuehui Duan, Yan Du, Yixuan Tang*, Wei Xu*. Advancements in Macrophage-Targeted Drug Delivery for Effective Disease Management. International Journal of Nanomedicine, 2023, 18:6915-6940. 2023.11.23. IF=6.6
9. Linlin Tao, Gang Cheng, Fangnan Lv, Ruiqi Wang, Nan Yang, Zuhang Xing, Boyu Gu, Siyuan Meng, Wei Xu*, Meirong Huo*. Synergistic strategy based on mild phototherapy and deep tumor hypoxia reversal comprehensively remodels the tumor microenvironment for improved immunotherapy. Chemical Engineering Journal, 2023, 472, 15:145092. 2023-08-11. IF=13.3
10. Xinyuan Zhou, Pan Zhang, Nan Liu, Xiao Zhang, Hui Lv, Wei Xu*, Meirong Huo*. Enhancing chemotherapy for pancreatic cancer through efficient and sustained tumor microenvironment remodeling with a fibroblast-targeted nanosystem. Journal of Controlled Release, 2023, 361:161–177. 2023.08.04. IF=10.5
11. Xiangwu Chen, Zeyu Jiang, Yang Lin, Cancan Yu, Xinxin Nie, Guixiang Xu, Wei Xu*, Yue Jiang*, Yuxia Luan*. Tumor lysates-constructed hydrogel to potentiate tumor immunotherapy. Journal of Controlled Release, 2023, 358:345-357. 2023-05-05. IF=10.5
12. Hui Lv, Hanxiao Liu, Ting Sun, Han Wang, Xiao Zhang and Wei Xu*. Exosome derived from stem cell: A promising therapeutics for wound healing. Frontiers in Pharmacology, 2022, 13:957771. 2022.08.08. IF=6.0
13. Xuling Chen, Jianbo Ji, Ke Zhou, Xiaohui Fan, Lingbing Li*, Wei Xu*. A novel multifunctional nanoparticle formed by molecular recognition between AS1411 aptamer and redox-responsive paclitaxel-nucleoside analogue prodrug for combination treatment of β-lapachone and paclitaxel. Colloids and Surfaces B: Biointerface, 2022, 212:112345. 2022.01.20. IF=6.0
14. Yuanyuan Li, Min Yang, Yanli Zhao, Lingbing Li*, Wei Xu*. Preparation and in vitro evaluation of amphiphilic paclitaxel small molecule prodrugs and enhancement of oral absorption. European Journal of Medicinal Chemistry, 2021, 215:113276.2021.02.06. IF=6.5
15. Ke Zhou, Yixin Zhu, Xuling Chen, Lingbing Li*, Wei Xu*. Redox- and MMP-2-sensitive drug delivery nanoparticles based on gelatin and albumin for tumor targeted delivery of paclitaxel. Materials Science and Engineering: C, 2020, 114:111006. 2020.05.05. IF=8.45
