姓名：王延风
硕士生导师
职称：教授
联系方式：wangyanfeng@sdfmu.edu.cn
研究方向：
1. 基于荧光探针成像的生物活性研究
围绕与疾病相关的生物靶点，以小分子荧光探针成像为研究手段，进行基于靶点结构的生物活性研究。
2. 化学生物学研究
通过合理设计、合成、生物筛选、分离、富集等手段，获得能与氨基酸、蛋白、有机小分子、无机离子等靶物质特异性结合的探针。
主要学术任职：
青海省“高端创新人才千人计划”（引进拔尖人才）
主要获奖情况（包括作为指导教师）：
1. 2021年度山东第一医科大学“十大重要科研进展”
2. 研究生中三人次获得“国家奖学金”；
3. 研究生中两人次获得“于金明科技创新基金”；
4. 研究生中两人次的毕业论文被评为“山东省优秀硕士学位论文”；
5. 研究生中一人次获得“山东省优秀硕士毕业生”称号；
主持科研课题：
1. 国家自然科学基金青年项目.，2014-2016年，25万元，已结题，主持；
2. 海西州科技计划项目.，2017.01-2019.12，30万元，已结题，主持；
3. 海西州科技计划项目.，2022.10-2024.10.，30万元，在研，主持；
4. 横向课题：Trifarotene中间体工艺开发及合成.，32万元，在研，主持；
5. 横向课题：小分子化合物类传感器的合成.，8万元，在研，主持。
近五年代表性论文（限第一作者和通讯作者）：
1.Yuanyuan Liu, Chengying Zhang, Yongchun Wei, Huimin Chen, Lingxiu Kong, Qixin Chen*, Yanfeng Wang*. De Novo-Designed landmine warfare strategy luminophore for super-resolution imaging reveal ONOO– evolution in living cells. Chemical Engineering Journal. 2021. 422,130151.
2.Yongchun Wei, Lingxiu Kong, Huimin Chen, Yuanyuan Liu, Yifei Xu, Han Wang, Guiqian Fang, Xintian Shao, Fei Liu, Yanfeng Wang*, Qixin Chen*.Super-resolution image-based tracking of drug distribution in mitochondria of a label-free naturally derived drug molecules. Chemical Engineering Journal. 2022. 429，
3.Yongchun Wei, Yuanyuan Liu, Yongqi Heb and Yanfeng Wang*. Mitochondria and lysosome-targetable fluorescent probes for hydrogen peroxide. Journal of Materials Chemistry B. 2021, 9, 908–920.
4.Lingxiu Kong, Chunpeng Jiao, Lingyu Luan, Sheng Li, Xia Ma, Yanfeng Wang*. Reversible Ni2+ fluorescent probe based on ICT mechanism and its application in bio-imaging of Zebrafish. Journal of Photochemistry & Photobiology, A: Chemistry. 2022，422,113555
5.Jiarao Sun, Xiaoli Cao, Wenjuan Lu, Yongchun Wei, Lingxiu Kong, Wei Chen, Xintian Shao, Yanfeng Wang*., Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications, Theranostics, 2023; 13(6): 1730-1758.
6.Chunpeng Jiao, Yuanyuan Liua, Jingxiang Pang, Wenjuan Lu, Pingping Zhang, Yanfeng Wang*. A simple lysosome-targeted probe for detection of hypochlorous acid in living cells. Journal of Photochemistry & Photobiology A: Chemistry. 392 (2020) 112399.
7.Yuanyuan Liu, Chunpeng Jiao, Yongchun Wei, Wenjuan Lu, Pingping Zhang, Yanfeng Wang*. A highly specific rhodamine B based turn-on fluorescent probe for nitric oxide and application in living cells. Tetrahedron. 76 (2020) 131622.
8. Chunpeng Jiao, Yuanyuan Liu, Wenjuan Lu, Pingping Zhang, Xia Ma and Yanfeng Wang*. A simple sensor based on 1,8-naphthalimide with large Stokes shift for detection of hypochlorous acid in living cells. RSC Advances. 2019, 9, 31196–31201.
9. Yuanyuan Liu, Chunpeng Jiao, Wenjuan Lu, Pingping Zhang and Yanfeng Wang *. Research progress in the development of organic small molecule fluorescent probes for detecting H2O2. RSC Advances. 2019, 9, 18027.
10. 矫春鹏, 刘媛媛, 路文娟, 张平平, 王延风*. 检测活性氮/活性氧的分子荧光探针. 有机化学. 2019, 39, 591-616.
11. A “weak acid and weak base” type fluorescent probe for sensing pH: mechanism and application in living cells. RSC Advances. Chunpeng Jiao, Jingxiang Pang, Li Shen,* Wenjuan Lu, Pingping Zhang, Yuanyuan Liu, Jing Li, Xianhui Jia and Yanfeng Wang *. 2019, 9, 20982.
12. Lingxiu Kong, Wenjuan Lu, Xiaoli Cao, Yongchun Wei, Jiarao Sun and Yanfeng Wang *. The design strategies and biological applications of probes for the gaseous signaling molecule hydrogen sulfide. Journal of Materials Chemistry B. 2022, 10, 7924–7954.
