导师：熊山
硕士生导师
职称：副研究员
邮箱：xiongshan@sdfmu.edu.cn
研究方向：
1. 药物临床前生物分析和PK/TK研究
2. 中药药效物质基础研究
主要学术任职：
1. 中国药理学会药物代谢专业委员会青年委员会委员
2. 中国中西医结合学会中药专业委员会青年委员
3. 山东省药理学会药物毒理专业委员会委员
4. Chinese Herbal Medicines（CHM，中草药英文版）、《中国新药与临床杂志》、《中国现代应用药学》、《中国医药工业杂志》、《现代药物与临床》和《中国药物应用与监测》青年（通讯）编委
主要获奖情况（包括作为指导教师）：
1. 2023年“学创杯”全国大学生创业综合模拟大赛（主体赛）校赛二等奖（第一指导教师）
2. 2020年度中国发明协会“发明创新奖”二等奖（银奖，证书号2020-CAICX-2-Y35，位次4/5）
主持课题：
1. 横向课题，新化合物PK性质筛选，2023/10-2026/12，在研，主持
2. 山东省自然科学基金面上项目，ZR2019MH051，基于入血活性成分追踪和代谢组学研究中药桑白皮抗高血压的药效物质基础及作用机制，2019/07- 2022/06，已结题，参与（3/5）
3. 山东省医学科学院科技计划，2016-41，莫诺苷对P-糖蛋白的影响及其作用机制研究，2017/01-2018/12，已结题，主持
近五年代表性论文（限第一作者和通讯作者）：
1. Jinglai Li, Lan Yin, Yuexin Li, Yutao Xue, Xiaoying Wang, Wenxia Xu, Zhenqing Zhang*, Shan Xiong*. Development and validation of an LC-MS/MS method for quantitative determination of LXT-101 sustained-release suspension, a novel drug in treating prostate cancer, in beagle plasma. Scientific Reports, 2025, 15: 11868.
2. Jinglai Li, Lan Yin, Yuexin Li, Junying Sun, Xiaoying Wang, Zhenqing Zhang*, Shan Xiong*. The stereoselective pharmacokinetics of the desmethyl - phencynonate hydrochloride in beagle dogs. Chirality, 2024, 36(5): e23669.
3. Shanshan Lei, Bo Li, Xiaowen Huang, Xupin Wang, Shan Xiong*, Rui Duan*, Linzi Li*. Structural identification of an polysaccharide isolated from Epimedium brevicornum and its beneficial effect on promoting osteogenesis in osteoblasts induced by high glucose. Biomedicine & Pharmacotherapy, 2023, 169: 115893.
4. Shan Xiong*, Xiaofan Li, Haiping Chu, Zhipeng Deng, Linying Sun, Jia Liu*, Yanling Mu and Qingqiang Yao*. Comparative pharmacokinetics of four major compounds after oral administration of Mori Cortex total flavonoid extract in normal and diabetic rats. Frontiers in Pharmacology, 2023, 14: 1148332.
5. Zixuan Chu, Min Lu, Teng Liu, Shan Xiong*, Yanling Mu. Pharmacokinetics and pharmacodynamics of Astragali Radix-Corni Fructus Herb-pair Extract, in kidney-yin deficiency model. Brazilian Journal of Pharmaceutical Sciences, 2022, 58: e19321.
6. Taiyuan Zhang*, Yan Yan, Yutao Xue, Shan Xiong*, Wenwen Ran, Qiao Xu. Pharmacokinetic study of hypaphorine, a potential agent for treating osteoclast-based bone loss, on rats using LC-MS/MS. Combinatorial Chemistry & High Throughput Screening, 2022, 25(11): 1889-1896.
7. Bo Li, Jin Wang, Xinyao Dou, Xinjie Zhang , Xianbei Xue, Qiao Xu, Wenwen Ran, Shan Xiong*. Development and validation of a LC-MS/MS method for quantification of mobocertinib (TAK-788) in plasma and its application to pharmacokinetic study in rats. Combinatorial Chemistry & High Throughput Screening, 2021, 24(9): 1410-1416.
8. Xiali Tang, Ying Zheng, Demin Jiao, Jun Chen, Xibang Liu, Shan Xiong*, Qingyong Chen*. Anlotinib inhibits cell proliferation, migration and invasion via suppression of c-met pathway and activation of ERK1/2 pathway in H446 Cells. Anti-Cancer Agents in Medicinal Chemistry, 2021, 21(6): 747-755.
9. Zixuan Chu, Mingxing Xue, Shan Xiong*. Development and validation of an LC-MS/MS method for quantitative determination of EAI045, a novel EGFR inhibitor, in rat plasma. Current Pharmaceutical Analysis, 2020, 16(3): 273-279.
10. Min Lu, Zixuan Chu, Liying Wang, Chen Liang, Peilu Sun, Shan Xiong*, Yanling Mu*. Pharmacokinetics and tissue distribution of four major bioactive components in rats after oral administration of Xianglian pill. Biomedical Chromatography, 2020, 34(3): e4770.
11. Bo Li, Xinglishang He, Shanshan Lei, Fuchen Zhou, Ningyu Zhang, Yehui Chen, Yuzhi Wang, Jie Su, Jingjing Yu, Linzi Li, Xiang Zheng, Rong Luo, Dorota Kołodyńska, Shan Xiong*, Guiyuan Lv*, Suhong Chen*. Hypertensive rats treated chronically with Nw-nitro-L-arginine methyl ester (L-NAME) induced disorder of hepatic fatty acid metabolism and intestinal pathophysiology. Frontiers in Pharmacology, 2020, 10: 1677.
