姓名：张仁帅
硕士生导师
职称：副教授
联系方式：rszhang@sdfmu.edu.cn
研究方向：
1. 抗炎药物筛选、靶点鉴定及作用机理研究
2. 降脂药物设计与开发
3. 基于天然产物探针的靶点发现
主要学术任职：
1. European Journal of Medicinal Chemistry等SCI期刊审稿人
2. Frontiers in Chemistry期刊客座编辑
3. 国际技术转移助理经理人
主要获奖情况（包括作为指导教师）：
主持科研课题：
1. 山东第一医科大学高层次人才经费，50万，2024-2029，在研，主持。
2. 新机制靶向抗肿瘤药物研究创新团队（山东省高等学校青年创新团队人才引育计划），DC2100002423，200万，2020-2024，完成，主持。
3. 兼具稳定性和靶向性的吉西他滨前药设计与评价，山东省自然科学基金，ZR2021QH212，15万，2022-2024，在研，主持。
4. 化学品危害测试关键技术确证和示范应用（横向课题，中国检验认证集团），5万，2019-2020，完成，主持。
近五年代表性论文（限第一作者和通讯作者）：
1. Fangjie Wang#, Lairong Song#, Qianqian Xu, Ang Jia, Xiangwei Meng*, Hongfei Jiang*, Renshuai Zhang*. Hypoxia-selective prodrug restrains tumor cells through triggering mitophagy and inducing apoptosis. European Journal of Medicinal Chemistry. 2025, (283), 117155. （中科院1区，IF=6.0）
2. Pengwei Chen#, Li Hao#, Quancai Li, Hao Wang, Huiqin Chen, Miao Zhang, Ang Jia, Hongfei Jiang*, Haofu Dai*, Renshuai Zhang*. Identification of targets and comparative study of administration methods for the lipid-lowering effects of fucoidan from saccharina japonica. International Journal of Biological Macromolecules. 2025, (290), 139102. （中科院1区，IF= 7.7）
3. Hongfei Jiang#, Qiuyu Gong#, Renshuai Zhang*, Hongye Yuan*. Tetrazine-based metal-organic frameworks. Coordination Chemistry Reviews. 2024, 499, 215501. （中科院1区，IF= 20.6）
4. Renshuai Zhang#, Na Xiao#, Qi Xu, Qiuyu Gong, Fandong Kong*, Hongfei Jiang*. Pleiotropic effects of a mitochondrion-targeted glutathione reductase inhibitor on restraining tumor cells. European Journal of Medicinal Chemistry. 2023, (248), 115069. （中科院1区，IF= 6.7）
5. Ang Jia#, Hongfei Jiang#, Wenjing Liu, Pengwei Chen*, Qi Xu*, Renshuai Zhang*, Jufeng Sun*. Novel application potential of cinaciguat in the treatment of mixed hyperlipidemia through targeting ptl/npc1l1 and alleviating intestinal microbiota dysbiosis and metabolic disorders. Pharmacological Research. 2023, (194), 106854. （中科院1区，IF= 9.1）
6. Xiaojin Peng, Chunte Feng, Ang Jia, Jiake Gao*, Renshuai Zhang*. Recovery of essential oils from the withered flowers of Magnolia soulangeana Soul.-Bod. by microwave-assisted hydrodistillation with uniform heating and its new application in the hypolipidemic field. Industrial Crops & Products. 2023, (204), 117355. （中科院1区，IF= 5.9）
7. Jiake Gao#, Hongfei Jiang#, Pengwei Chen*, Renshuai Zhang*, Ning Liu *. Photosensitizer-based small molecule theranostic agents for tumor-targeted monitoring and phototherapy. Bioorganic Chemistry. 2023, (136), 106554. （中科院1区，IF= 5.1）
8. Binghuan Huang#, Bing Liang #; Renshuai Zhang*, Xing, Dongming*. Molecule fluorescent probes for adenosine triphosphate imaging in cancer cells and in vivo. Coordination Chemistry Reviews. 2022, 452, 214302.（中科院1区，IF= 20.6）
9. Xiaofei Qin, Hanyi Zhang, Xin Xing, Peng Wang, Jiaqi Yan, Daishun Liu, Qiuyu Gong*, Renshuai Zhang*, Zhang, Hongbo*. Robust strategies in nuclear-targeted cancer therapy based on functional nanomaterials. Materials & Design. 2022, (221), 110999. （中科院1区，IF= 8.4）
10. Renshuai Zhang*, Wenjing Liu, Jun Zeng, Jingsen Meng, Hongfei Jiang, Jie Wang, Dongming Xing*. Niemann-Pick C1-Like 1 inhibitors for reducing cholesterol absorption. European Journal of Medicinal Chemistry. 2022, (230), 114111. （中科院1区，IF= 6.7）
11. Jie Wang, Qian Li, Jiao Xue, Wujun Chen, Renshuai Zhang*, Dongming Xing *. Shape matters: Morphologically biomimetic particles for improved drug delivery. Chemical Engineering Journal. 2021, 410, 127849-127864.（中科院1区，IF= 15.1）
12. Hongfei Jiang, Wujun Chen, Jie Wang*, Renshuai Zhang*. Selective N-terminal modification of peptides and proteins: Recent progresses and applications. Chinese Chemical Letters. 2021, 14, 58. （中科院1区，IF= 9.1）
13. Hongfei Jiang#, Qin, Xiaofei#, Wang, Qi#, Qi Xu, Jie Wang, Yudong Wu, Wujun Chen, Chao Wang, Tingting Zhang, Dongming Xing, Renshuai Zhang*. Application of carbohydrates in approved small molecule drugs: A review. European Journal of Medicinal Chemistry. 2021, 223, 113633.（中科院1区，IF= 6.7）
14. Renshuai Zhang*, Zhengming Song, Xueting Wang, Jiao Xue, Dongming Xing*. One-step modification to identify dual-inhibitors targeting both pancreatic triglyceride lipase and Niemann-Pick C1-like 1. European Journal of Medicinal Chemistry. 2021, (216), 113358. （中科院1区，IF= 6.7）
