
姓名:刘媛媛
硕士生导师
职称:副教授
联系方式:15044043490@163.com
研究方向:
1. 基于质谱的药物分析,包括:中药成分鉴定、代谢组学、药代动力学、PK-PD等。
2. 中药治疗阿尔兹海默症和类风湿性关节炎等疾病作用机制的研究。
主持在研项目:
1. 国家自然科学基金青年项目,82204749,一种基于多组合技术五味子木脂素抗AD大鼠PK-PD模型建立策略的研究,2023/01-2025/12,30万元。
2. 山东省自然科学基金青年项目,ZR2021QH092,基于“代谢组学-PMRM-微透析”组合技术的PK-PD模型研究五味子总木脂素药效物质基础及作用机制,2022/01-2024/12,15万元。
近五年代表性成果和论文(限第一作者和通讯作者):
1. 山东第一医科大学与河南赛尔金生物医学科技有限公司签订关于靶向THRβ激动剂治疗NASH项目的《专利权转让合同》,2.04亿元。参与人,DMPK组负责人。
2. Zuohua Zhang, Jinpeng Zhang, Shuo Zhao, Tingtao Peng, Mei Zhang, Xizhu Xu, Ke Li*, Yuanyuan Liu*, Synovial tissue metabolomics analysis of the therapeutic effects of stir-fried Xanthii Fructus on rheumatoid arthritis in rats[J]. Journal of Chromatography B, 2023, 1216: 123594.
3. Shuo Zhao, Jinpeng Zhang, Yufeng Chen, Xinyuan Cui, Haiqing Liu, Ying Yan, Yuexiang Sun, Yongxiu Qi, Yuanyuan Liu*, The comprehensive mechanism underlying Schisandra polysaccharide in AD-like symptoms of Aβ25-35-induced rats based on hippocampal metabolomics and serum lipidomics techniques[J]. Journal of Pharmaceutical and Biomedical Analysis, 2023, 236: 115717.
4. Jinpeng Zhang, Xinyuan Cui, Shuo Zhao, Zenghui Chang, Junshuo Zhang, Yufeng Chen, Jiale Liu, Guohao Sun, Yiyuan Wang and Yuanyuan Liu*, Establishment of a pharmacokinetics and pharmacodynamics model of Schisandra lignans against hippocampal neurotransmitters in AD rats based on microdi-alysis liquid chromatography-mass spectrometry[J]. Frontiers in Pharmacology, 2024, 15:1342121.
5. Xinyuan Cui, Zhaoqi Ding, Yujie Ji, Jiale Liu, Zenghui Chang, Junshuo Zhang, Xinyi Wang, Kai Liu*, Yuanyuan Liu*, Stir-baked Xanthii fructus ameliorates adjuvant arthritis by regulating gut microbiota, short-chain fatty acids and metabolites[J]. Frontiers in Microbiology, 2025, 3: 1599529.