姓名：张春雨
硕士生导师
职称：副教授
联系方式：zhangchunyu@sdfmu.edu.cn
研究方向：
1. 铂类抗肿瘤药物设计开发及应用;
2. 基于金属团簇药物/探针的生物分析研究;
3. 基于先进光源的单细胞同步辐射成像分析。
主要学术任职：
1. BMEMat期刊青年编委；
2. Exploration期刊青年编委；
3. 担任Advanced Materials, Advanced Functional Materials, Nano Today等期刊审稿人
主持科研课题：
1. 国家自然科学基金, 青年基金项目C类, 22504076，2026/01-2028/12，30万，在研，主持；
2. 中国博士后科学基金, 面上项目, 2022M711974, 2022/06-2023/09, 8万, 已结题, 主持;
3. 山东第一医科大学青年科学基金培育资助计划项目, 202201-003, 2022/10-2024/10, 10万, 已结题, 主持;
4. 山东省医药卫生科技项目, 青年项目, 202313030397, 2024/01-2025/12, 5万, 已结题, 主持;
5. 山东第一医科大学高层次人才引进经费资助项目, 2023/09-2028/08, 100万, 在研, 主持。
近五年代表性论文（限第一作者和通讯作者）：
(1) Xuan, Yin, Mengyuan Yi, Ruihan Li, Yanling Mu, Qingqiang, Yao, Chunyu Zhang,* Fluorescence and Catalytic Dual-Functionalized Platinum Clusters Probe Achieves Specific Staining of Cell Nuclei. ACS Materials Letters 2026. https://doi.org/10.1021/acsmaterialslett.6c00006
(2) Chao Xu, Yuan Zhang, Chunyu Zhang,* Xueyun Gao,* Gold nanoclusters - A promising atomically precise atomic aggregation-based drug and its biomedical applications. Nano Today 2026, 67, 102985.
(3) Xuan, Yin, Ruihan Li, Mengyuan Yi, Yanling Mu, Qingqiang, Yao, Chunyu Zhang,* Protein-Protected Water-Soluble Platinum Nanoclusters as Fluorescent Probe for Trypsin Detection. ACS Applied Nano Materials 2026, 9, 2916-2923.
(4) Ruihan Li,# Chuanke Chong,# Mei Liu, Xuan Yin, Yan Li, Ying Li, Qingqiang Yao, Yanling Mu,* Chunyu Zhang,* Platinum(IV) Prodrug-Coupled TAT Nuclear-Targeting Peptide for Drug Delivery and High Antitumor Efficacy with Low Toxicity. ACS Applied Materials & Interfaces 2025, 17, 41792−41805.
(5) Ruihan Li, Xuan Yin, Chuanke Chong, Yan Li, Qingqiang Yao, Yanling Mu,* Chunyu Zhang,* Exploring the Relationships between Targeted Structures and Antitumor Activities of Nuclear-Targeted Polypeptide-Functionalized Platinum(IV) Prodrugs. Molecular Pharmaceutics 2025, 22, 6349−6356.
(6) Yinxue Fu,# Chunhui Dou,# Xiaoyang Gao,# Shanping Ji, Xuemei Zhao, Jingwen Xue, Hao Yang, Nannan Song, Chunyu Zhang,* Changlong Wang,* and Yulei Li*, Design, Synthesis, and Biological Evaluation of Arginine N-Glycosylation Stapled Peptides with Potent Antitumor Activity In Vivo. Journal of Medicinal Chemistry 2025, 68, 20435−20448.
(7) Chao Xu, Juanjuan Guo, Qinqin Zheng, Mingchuan Yang, Zhenduo Han, Na Zhang, Chunyu Zhang,* Hongping Chen* and Xiangchun Zhang,* Personalized design enzyme-like activity theanine coated Pt clusters for catalytic damage of bacterial and infection management. Chemical Engineering Journal 2025, 505, 159309.
(8) Chao Xu, Dongfang Xia, Xiangchun Zhang, Qingqiang Yao, Yaling Wang,* Chunyu Zhang,* In situ analysis of metallodrugs at the single-cell level based on synchrotron radiation technology. TrAC-Trends in Analytical Chemistry 2024, 171, 117515.
(9) Chunyu Zhang,* Na Zhang, Wenchao Niu, Ruihan Li, Yanna Liu, Yanling Mu, Chao Xu,* Qingqiang Yao,* Xueyun Gao,* Ultrasmall platinum nanoclusters: A potent chemotherapeutic drug for cancer-specific DNA damage with optimizing therapeutic efficacy while minimizing systemic toxicity. Nano Today 2024, 55, 102195.
(10) Chunyu Zhang,# Kai Zhang,# Yanyan Cui,# Yuecong Guo, Chuan Wang, Chao Xu, Qingqiang Yao, Yuliang Zhao, Chunying Chen,* Yaling Wang,* Multifunctional Nanoprobe for 3D Nanoresolution Imaging of Intact Cell HER2 Protein with Hard X-ray Tomography. Analytical Chemistry 2023, 95, 2129-2133. (Cover article)
(11) Chunyu Zhang,# Chao Xu,# Xueyun Gao,* Qingqiang Yao,* Platinum-based Drugs for Cancer Therapy and Anti-tumor Strategies. Theranostics 2022, 12, 2115-2132. (Highly Cited Paper)
(12) Zhesheng He,# Fei Ye,# Chunyu Zhang,# Jiadong Fan,# Zhongying Du, Wencong Zhao, Qing Yuan, Wenchao Niu, Fuping Gao, Bo He, Peng Cao, Lina Zhao, Xuejiao Gao, Xingfa Gao, Bo Sun, Yuhui Dong, Jincun Zhao, Jianxun Qi, Xing-Jie Liang, Huaidong Jiang,* Yong Gong,* Wenjie Tan,* Xueyun Gao,* A Comparison of Remdesivir Versus Gold Cluster in COVID-19 Animal Model: A Better Therapeutic Outcome of Gold Cluster. Nano Today 2022, 44, 101468. (co-first author）
(13) Chunyu Zhang, Shengkun Yao, Chao Xu, Yanan Chang, Yunbing Zong, Kai Zhang, Xiangzhi Zhang, Lijuan Zhang, Chunying Chen, Yuliang Zhao, Huaidong Jiang,* Xueyun Gao,* Yaling Wang,* 3D Imaging and Quantification of the Integrin at a Single-Cell Base on a Multisignal Nanoprobe and Synchrotron Radiation Soft X-ray Tomography Microscopy. Analytical Chemistry 2021, 93, 1237-1241.
(14) Chunyu Zhang, Liang Gao,* Qing Yuan, Lina Zhao, Wenchao Niu, Pengju Cai, Jiaojiao Li, Xu Han, Zhesheng He, Fuping Gao, Yaling Wang, Huaidong Jiang, Zhifang Chai, Xueyun Gao,* Is GSH Chelated Pt Molecule Inactive in Anti-Cancer Treatment? A Case Study of Pt6GS4. Small 2020, 16, 2002044.
