优秀校友个人简介 |
史文娜，女，1982年06月出生，2007年毕业于山东第一医科大学（原泰山医学院）药学院制药工程专业，获得学士学位；2010年毕业于山东大学药学院临床药学专业，获得硕士学位；2017年毕业于首都医科大学基础医学院药理学专业，获得博士学位。现工作单位山东第一医科大学附属肿瘤医院，副主任药师。主要工作经历，2010年-2020年山东省肿瘤医院药学部临床药学负责人，主管药师；2021年-至今，山东第一医科大学附属肿瘤医院药学部质子中心负责人，副主任药师；2020.02-至今，山东大学和山东省医学科学院联合培养，博士后。主要研究方向为抗肿瘤机制及抗感染耐药机制，为首国家发明专利1项，主持省部级科研课题4项，发表SCI论文十余篇，副主编及参编书籍5部。 附研究成果如下： Ø Wenna Shi, Zuozhong Chen, Xu Chen, Lili Cao, Ping Liu, Shujuan Sun*. The combination of minocycline and fluconazole causes synergistic growth inhibition against Candida albicans: an in vitro interaction of antifungal and antibacterial agents. FEMS Yeast Res. 2010, 10(7). Ø Wenna Shi, Hui Li, Yuguo Liu, Xiang Zhang, and Shujuan Sun. The Effect of Fluconazole in Combination with Rifampin in vitro on Candida albicans Biofilms. Anti-Infective Agent 2013,11(2):136-143. Ø A series of books on the main points of drug treatment for common diseases, Oncology, Deputy Editor-in-Chief, people's Health Publishing House (ISBN No.: 9787117199674), 2015, Beijing Ø Xinfeng Yu ; Ruilian Li; Wenna Shi ; Tao Jiang; Yufei Wang; Cong Li; Xianjun Qu. Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells. Biomedicine & Pharmacotherapy 2015, 77: 37-44. Ø Wenna Shi, Shuxiang Cui, Zhiyu Song, Shuqing Wang, Shiyue Sun, Xinfeng Yu, Ye Li, Yuhang Zhang, Zuhua Gao*, Xianjun Qu*.Overexpression of SphK2 contributes to ATRA resistance in colon cancer through rapid degradation of cytoplasmic RXRα by K48/K63-linked polyubiquitination. Oncotarget. 2017,8:39605-39617. Ø China invention patent, Antifungal composition and its use (patent no. ZL 2016 10343488.7), State intellectual property Office of China, Grant time September 4, 2018, The first place. Ø Xiaohui Tang, Haisheng Chen, Guanxuan Chen, Cunxian Duan, Qing Fan, Yanhong Wang, Zhijun Li, Wenna Shi*, Yuguo Liu*. Sphingosine 1-phosphate correlation with radiotherapy through qualitative determination by LC-MS/MS. Thoracic cancer. Thoracic Cancer ,2020, 116(6) Ø Haisheng Chen, Hui Li, Cunxian Duan, Chuanjie Song, Zuoliang Peng, Hui Li, Wenna Shi*. Azoles resistance reversal by oridonin in Candida albicans. 2020, mycoses. Journal of Global Antimicrobial Resistance , 2021, 24: 296-302 . Ø Yuhang Zhang; Wenna Shi; Shuhua Wu; Rongrong Miao; Shiyue Sun; Dongdong Luo; Shengbiao Wan; Zhikun Guo; Wenyu Wang; Xinfeng Yu; Shuxiang Cui; Xianjun Qu. SphK2 confers 5-fluorouracil resistance to colorectal cancer via upregulatingH3K56ac-mediated DPD expression, Oncogene , 2020, 3929(29) Ø Wei Tian; Yinping Sun; Yuping Cheng; Xiao Ma; Weina Du; Wenna Shi*; Qisen Guo. Arsenic sulfide reverses cisplatin resistance in non-small cell lung cancer in vitro and in vivo through targeting PD-L1, Thoracic Cancer , 2021, 12(19): 2551-2563 |
